When Jennifer Olsen receives a sinister phone call from a man named Anton LeDoux, informing her that she will never again see her sister Angela, the team investigate. They discover the real LeDoux died in 1948, but realise they are embroiled in a deadly game of cat and mouse when they find the body of a young woman next to his grave.
To Jennifer’s relief, it is not Angela but a working girl named Nikki. She was killed and dumped at the graveyard with her eyes removed and replaced with glass substitutes. The team determine that Nikki has wounds approximately 48 hours old, while Angela has been missing for less than 24 hours. She may still be alive, but the detectives only have some barefoot prints found near the grave to go on...
Horatio and the team protect a Mexican sheriff who is being targeted by the Brazilian gang Mala Noche.
The team have to pick up the pieces when a violent storm blows away a dead body and all of the surrounding evidence.
After the body of a young man is found in a hotel complex, the CSI team delves into the steamy, secretive world of Miami's gigolos.