When CSIs are let loose in the Big Apple, you just know they're going to encounter some disgraceful criminals. Mac Taylor and Jo Danville lead an indomitable team of forensic experts from a state-of-the-art Manhattan high-rise.
DB Russell visits New York in a joint effort to find Mac's missing girlfriend Christine, as Mac's principles are put to the test.
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A shooting at Mac's local coffee shop leaves one man dead. Piecing together the evidence, Mac learns the perpetrator was a federal informant.
Mac is forced to face his personal demons when a defendant facing a murder trial insists that the CSI team's evidence is incorrect.