At a motel, seriously injured Dewey Crowe is awakened by Lance, the Tramble Correctional Facility nurse and Ash Murphy’s partner in crime. Pointing to fresh surgical scars as evidence, Lance convinces Dewey that his kidneys have been removed and demands $20,000 for their return. As Dewey embarks on a frantic crime spree, Raylan and Rachel track him to the motel and find evidence of the bizarre plan to resell his organs.
Meanwhile, after using Devil's cell phone to expose Tanner Dodd, Boyd and Johnny beat him violently before sending him back to his boss, Robert Quarles, with a warning.
At the Tyree Medical Centre, Raylan coerces Ash into disclosing the details of his partner’s organ sales scheme before pressing his nurse, Layla, for the names of any doctors who might have helped. Still on his rampage, Dewey holds up a mini mart and ends up trapped in a storeroom after being shot by a stubborn cashier, leaving Raylan to take over negotiations.
Later, as Boyd looks to enlist Doc Stern in a Oxycontin theft ring, Raylan returns to question Layla about the fake kidney theft, only to be ambushed by Lance.
The battle for the control of Harlan's oxycodone business heats up, while Winona questions whether Raylan will ever change his ways.
Dickie goes looking for his late mother Mags's money after breaking out of jail, and Boyd experiences some dissention amongst the ranks.
A hit is ordered on Raylan as he comes up against Robert Quarles for the first time.